Here’s what you’ll need to know in order to appreciate and enjoy this week’s BioGPS Featured Article – Chemoproteomics reveals Toll-like receptor fatty acylation | The Su Lab.
Palmitoylation is a kind of fatty acylation where a palmitoyl group (derived from palmitic acid see below) is added to specific amino acid residues on a protein (usually cysteine, but some times serine or threonine)
This post-transcriptional modification of proteins can play an important regulatory role by affecting where the proteins localize, how they interact with other proteins, etc.
In spite of playing an important regulatory role, the palmitoyl proteome has yet to be fully elucidated. The researchers behind this week’s BioGPS featured article used bioinformatics to identified over 200 potential palmitoylation targets, including Toll-Like Receptor 2 which plays an important role in the immune response.