Here’s the skinny on this paper:
- Investigated By: Researchers for 8 renal transplant centers
- Has implications for: Renal transplant patients and their medical providers (pending further validation studies, regulatory trials and approvals)
WHY: 15-20% of renal transplant patients experience acute rejection, but the current method to detect acute rejection involves taking a biopsy following suspicious blood test results (in other words, more surgery!). Worse yet, the suspicious blood test results are non-specific for acute rejection, and usually a bit too late when it is indicative of acute rejection.
WHAT: A blood test to detect risk of acute kidney transplant rejection called the Kidney Solid Organ Response Test (kSORT)
HOW: Analyzing gene expression of >500 blood samples from 436 renal transplant patients divided into 1 training set and 3 validation sets.